Home  |  News  |  Sitemap  |  Contact Us  |  Login
Advertise With Us
Latest Notification
  • banner1
  • banner2
  • banner3
  • banner4
  • banner5
  • banner6
  • banner7
banner11 banner22 banner33 banner44 banner45 banner46 banner47

 Adverse Cases


Back Reported Adverse Drug Reaction Cases
Clarithromycin + digoxin Interactions
A 75 year old female who had been taking digoxin 250 g daily for almost four years was admitted with digoxin toxicity (4.2 nmol/L) on the third day after commencement of clarithromycin 250mg twice daily. The dose of digoxin was halved and clarithromycin stopped. She was discharged eight days later. Digoxin bioavailability is around 70% because p-glycoprotein in the gut wall pumps it back into the gut lumen, reducing absorption. Clarithromycin, and other macrolide antibiotics, inhibit the p-glycoprotein pump, increasing the amount of digoxin absorbed.
clozapin 75 clozapin laborkontrollen clozapin orifarm
itraconazol kaufen itraconazol bula itraconazol buy
References:
  1. Juurlink DN, Mamdani M, Kopp A, Laupacis A, Redelmeier DA. Drug-drug interactions among elderly patients hospitalized for drug toxicity. JAMA 2003;289:1652-58.

Back


» Home
» Latest Notification
» New Drugs
» Import of Drugs
» Drug Prices
» Legislations
» Applications Forms
» Quackwatch
» Forms & Fees
» Licence Conditions
» Schedules
» Health, Pharma. Policies & Reports
» Ayurvedic
» Govt. Bodies
» Information Centre
» Directory
» Alert
» Regulatory News
» Research News
» News in Hindi
» Login
» Contact Us

Copyright © DrugsControl.org - Jaipur, INDIA. All Rights Reserved   |   Disclaimer   |   Sitemap

Site last updated: December 30, 1899 at