Home  |  News  |  Sitemap  |  Contact Us  |  Login
Advertise With Us
Latest Notification
  • banner1
  • banner2
  • banner3
  • banner4
  • banner5
  • banner6
  • banner7
banner11 banner22 banner33 banner44 banner45 banner46 banner47

 Adverse Cases


Back Reported Adverse Drug Reaction Cases
Serious reaction reminders: cefaclor and serum sickness-like reactions in children

The association between cefaclor and serum sickness-like reactions (SSLR), particularly in children, has long been recognised.1 These reactions are characterised by a variety of rashes, which include urticaria or erythema multiforme, with or without angioedema, accompanied by arthritis/arthralgia, with or without fever.

The reactions are rare but occur more often after a second or subsequent course of treatment. Onset time is often a few days after cefaclor is commenced and signs and symptoms typically subside a few days after the drug is ceased. However, onset may also be delayed and occur 7-21 days after stopping cefaclor. Children are more susceptible than adults, but the underlying reasons are not clear.

Despite a steady decline of cefaclor prescriptions under the Pharmaceutical Benefits Scheme (PBS) and the cautionary note associated with the PBS entries ("Caution: "Serum sickness-like reactions have been reported with this drug, especially in children"), we continue to receive about 10 reports per year of cefaclor-related SSLR in children.

If cefaclor must be prescribed to a child, the parents/caregivers should be advised to remain alert for the development of new or worsening symptoms that might indicate a hypersensitivity reaction to the drug and to contact their doctor immediately if there are concerns.

References

  1. ADRAC. ADRAC. Cefaclor in the young patient: arthritis and arthralgia. Aust Adv Drug React Bull 1995; 14 (3).
References:
Australian Adverse Drug Reactions Bulletin
Volume 28, Number 2, April 2009

Back


» Home
» Latest Notification
» New Drugs
» Import of Drugs
» Drug Prices
» Legislations
» Applications Forms
» Quackwatch
» Forms & Fees
» Licence Conditions
» Schedules
» Health, Pharma. Policies & Reports
» Ayurvedic
» Govt. Bodies
» Information Centre
» Directory
» Alert
» Regulatory News
» Research News
» News in Hindi
» Login
» Contact Us

Copyright © DrugsControl.org - Jaipur, INDIA. All Rights Reserved   |   Disclaimer   |   Sitemap

Site last updated: December 30, 1899 at